منابع مشابه
Unraveling the Mystery of Protein Folding
sis. Mad Cow disease. An inherited form of emphysema. Even many cancers. Recent discoveries show that all these apparently unrelated diseases result from protein folding gone wrong. As though that werent enough, many of the unexpected difficulties biotechnology companies encounter when trying to produce human proteins in bacteria also result from something amiss when proteins fold. What exactl...
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متن کاملUnraveling the Mystery of Goldblatt Hypertension.
In hypertension caused by unilateral renal artery stenosis, the nonstenotic kidney becomes renin depleted but fails to prevent hypertension. The nonstenotic kidney mysteriously develops elevated intrarenal angiotensin II (ANG II) content. Rats chronically infused with ANG II exhibit a similar hypertensive process. The augmentation of intrarenal ANG II is due to receptor-mediated internalization...
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The 132-year historical rainfall record reveals that severe droughts in India have always been accompanied by El Niño events. Yet El Niño events have not always produced severe droughts. We show that El Niño events with the warmest sea surface temperature (SST) anomalies in the central equatorial Pacific are more effective in focusing drought-producing subsidence over India than events with the...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2014
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth.3089